Geneimprint

• 2005 Durham
• 2002 Washington
• 2002 London
• 2001 Osaka
• 1999 Dublin
• 1998 Durham

2005: Environmental Epigenomics, Imprinting and Disease Susceptibility

Durham, NC: The 'early origins hypothesis' of Barker states that environmental factors, such as nutrition acting in early life, program the risks for adverse health outcomes in adult life. This hypothesis is now supported by a number of epidemiological studies performed worldwide. Environmental perturbations during gestation are also known to affect adult phenotype by altering gene expression through the modification of DNA  methylation and chromatin structure. The objective of this conference is to discuss the evidence that genomic elements, such as transposons and imprinted genes, can function as epigenetically labile targets for linking environmental exposures during early development to adult susceptibility of developing medical conditions such as asthma, cancer, behavioral disorders, cardiovascular disease, diabetes, and obesity.

ORGANIZERS: Randy L. Jirtle (Duke University) and Fred Tyson (NIEHS)

Invited Speaker Presentations

The following is a list of the Environmental Epigenomics conference speakers and their addresses, along with links to their presentation abstracts and recordings.

• Trevor Archer — Laboratory of Molecular Carcinogenesis, NIEHS
  PO Box 12233; Research Triangle Park, NC 27709; United States • p: +1 919-316-4565 / f: +1 919-316-4566 / e: archer1@niehs.nih.gov
  • "Hormonal Regulation of Transcription via Chromatin and Epigenetics"
    Abstract / Video
• Marisa Bartolomei — Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine
  363 Clinical Research Building, 415 Curie Boulevard; Philadelphia, PA 19104; United States • p: +1 215-898-9063 / f: +1 215-573-6434 / e: bartolom@mail.med.upenn.edu
  • "Effects of Embryo Culture on Epigenetic Regulation in the Mouse"
    Abstract / Video
• Manel Esteller — Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO)
  Melchor Fernandez Almagro 3; Madrid 28029; Spain • p: +34 91-2246940 / f: +34 91-2246923 / e: mesteller@cnio.es
  • "Epigenetic Breakdown of Cancer Cells: From DNA Methylation to Histones"
    Abstract / Video
• Andrew Feinberg — Department of Medicine, Molecular Biology and Genetics, and Oncology, Johns Hopkins University School of Medicine
  Ross Building 1064, 720 Rutland Ave.; Baltimore, MD 21205; United States • p: +1 410-614-3489 / f: +1 410-614-9819 / e: afeinberg@jhu.edu
  • "Epigenetics: Tying it All Together"
    Abstract / Video
• David Haig — Department of Organismic and Evolutionary Biology, Harvard University
  26 Oxford Street; Cambridge, MA 02138; United States • p: +1 617-496-5125 / f: +1 617-495-5667 / e: dhaig@oeb.harvard.edu
  • "Epigenetics and the Lamarckian Temptation"
    Abstract / Video
• Andrew Hoffman — Department of Medicine, Stanford University
  Palo Alto, CA 94304; United States • p: 650-858-3930 / f: 650-856-8024 / e: arhoffman@stanford.edu
  • "Regulation of Imprinting in Cancer"
    Abstract / Video
• Jean-Pierre Issa — Department of Leukemia, M.D. Anderson Cancer Center
  Unit 425, 1515 Holcombe Street; Houston, TX 77030; United States • p: 914-351-2368 / f: 914-351-2118 / e: jpissa@mail.mdanderson.org
  • "DNA Methylation and Epigenetics in the Pathogenesis of Age-Related Diseases"
    Abstract / Video
• Randy Jirtle — Department of Oncology, University of Wisconsin-Madison
  Durham, NC 27710; United States • p: 919-684-2770 / f: 919-684-5584 / e: jirtle@radonc.duke.edu
  • "Biological Consequences of Divergent Evolution of M6P/IGF2R Imprinting"
    Abstract / Video
• Joanne Kurtzberg — Department of Pediatrics - Bone Marrow Program, Duke University Medical Center
  Durham, NC 27710 ; United States • p: 919-668-1100 / f: 919-668-1183 / e: kurtz001@mc.duke.edu
  • "Treatment of Rare Genetic Disorders with Umbilical Cord Blood Transplantation: Hints about Tissue Repair and Regeneration"
    Abstract / Video
• Jeannie Lee — Howard Hughes Medical Institute, Department of Genetics , Harvard Medical School
  Boston, ME; United States • p: 617-726-5943 / f: 617-726-6893 / e: lee@frodo.mgh.harvard.edu
  • "Genomic imprinting and X-inactivation: Does ontogeny recapitulate phylogeny?"
    Abstract / Video
• Haifan Lin — Department of Cell Biology, Duke University Medical Center
  Durham, NC 27710 ; United States • p: 919-684-3169 / f: 919-684-5481 / e: h.lin@cellbio.duke.edu
  • "Drosophila PIWI Interacts with Non-coding Small RNA to Regulate the Epigenetic Status of Telomeric Associated Sequences"
    Abstract / Video
• Victor Lobanenkov — Section of Molecular Pathology, Laboratory of Immunopathology, National Institutes of Health
  Twinbrook I Building, 5640 Fishers Lane ; Rockville, MD 20852; United States • p: 301-435-1690 / f: 301-402-0077 / e: vlobanenkov@niaid.nih.gov
  • "Epigenetic Regulation of Human Genome Involves CTCF/BORIS-Binding Regions"
    Abstract / Video
• John McLachlan — Center for Bioenvironmental Research, Tulane and Xavier Universities
  New Orleans, LA 70112 ; United States • p: 504-988-6910 / f: 504-988-6428 / e: john.mclachlan@tulane.edu
  • "Estrogen Associated Gene Imprinting and Developmental Diseases"
    Abstract / Video
• Adele Murrell — Senior Cancer Research Fellow, Hutchison/MRC Research Centre, Department of Oncology, University of Cambridge
  Hills Road; Cambridge CB2 2XZ; United Kingdom • p: 01223-763377 / f: 01223-763262 / e: amm207@cam.ac.uk
  • "Higher Order Chromatin Structure and the Epigenome: Implications for Cancer Research"
    Abstract / Video
• Marcus Pembrey — Institute of Child Health, UCL
  Picketts South, Picketts Lane; Redhill RH1 5RG; United Kingdom • p: +44-1293-771-202 / f: +44-1293-771-202 / e: M.Pembrey@bristol.ac.uk
  • "Sex-specific, Male-line Transgenerational Responses in Humans"
    Abstract / Video
• Jorge Piedrahita — United States
  • "Epigenetic Dysregulation: From Somatic Cell Nuclear Transfer (SCNT) to Intrauterine Growth Restriction (IUGR)"
    Abstract / Video
• Bruce Richardson — Department of Medicine, University of Michigan
  5310 Cancer Center and Geriatrics Center; Ann Arbor, MI 48109-0940; United States • p: 734-763-6940 / f: 734-936-9220 / e: Brichard@umich.edu
  • "Environment, Epigenetics and Autoimmunity"
    Abstract / Video
• Douglas Ruden — Department of Environmental Health Sciences, University of Alabama at Birmingham
  530 Ryals Public Health Building, 1665 University Boulevard; Birmingham, AL 35294-0022; United States • p: 205-934-7042 / f: 205-934-7142 / e: douglasr@uab.edu
  • "Hsp90 and Epigenetic Canalization in Drosophila: Implications for Human Health"
    Abstract / Video
• Gerald Schatten — Departments of Obstetrics , University of Pittsburgh School of Medicine
  204 Craft Avenue ; Pittsburgh, PA 15213; United States • p: 412-641-2400 / f: 412-641-2410 / e: gschatten@pdc.magee.edu
  • "Epigenomic Regulations of Patient-Specific and Primate-Specific Embryonic Stem Cells Derived after Nuclear Transfer: Differences between ESC from Fertilized Blastocysts versus NT-ESC"
    Abstract / Video
• David Schwartz — University of Colorado
  12631 E 17th Ave; Aurora, CO 80045; United States • e: david.schwatrz@ucdenver.edu
  • "A Vision for NIEHS"
    Abstract / Video
• David Skuse — Behavioural and Brain Sciences Unit, Institute of Child Health
  30 Guilford Street ; London WC1N 1EH ; United Kingdom • p: +44-207-831-0975 / f: +44-207-831-7050 / e: dskuse@ich.ucl.ac.uk
  • "X-linked Genes and Mental Functioning"
    Abstract / Video
• Moshe Szyf — Department of Pharmacology and Therapeutics , McGill University
  3655 Sir William Osler Promenade, McGill University ; Montreal, Quebec H3G 1Y6; Canada • p: 514-398-7107 / f: 514-398-6690 / e: mszyf@pharma.mcgill.ca
  • "Reversal of Maternal Programming of Stress Responses in Adult Offspring Through Methyl Supplementation"
    Abstract / Video
• Donata Vercelli — College of Medicine , University of Arizona
  1501 North Campbell Avenue, Suite 2349; Tucson, AZ 85724-5030 ; United States • p: 520-626-6387 / f: 520-626-6970 / e: donata@resp-sci.arizona.edu
  • "Epigenetic Regulation of Allergic Inflammation"
    Abstract / Video
• Paul Wade — Laboratory of Molecular Carcinogenesis , NIEHS
  Research Triangle Park; , NC 27709 ; United States • p: 919-541-3392 / f: 919-541-0146 / e: wadep2@niehs.nih.gov
  • "Epigenetic Regulation and Control of Cell Fate"
    Abstract / Video
• Robert Waterland — Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, Children's Nutrition Research Center
  1100 Bates St., Rm. 9070 ; Houston, TX 77030 ; United States • p: 713-798-0304 / f: 713-798-7171 / e: waterland@bcm.tmc.edu
  • "Early Nutrition and the Development of Epigenotype"
    Abstract / Video
• Emma Whitelaw — School of Molecular and Microbial Biosciences, University of Sydney
  Biochemistry Building, Butlin Avenue; New South Wales 2006; Australia • p: +61-2-9351-2549 / f: +61-2-9351-4726 / e: e.whitelaw@mmb.usyd.edu.au
  • "KEYNOTE ADDRESS: Metastable Epialleles in Mice and Humans"
    Abstract / Video

Attendee Presentations

• Gregory Bean — Division of Medical Oncology, Duke University Medical Center
  Box 2628, Room 221A, MSRB; Durham, NC 27710; United States • p: 919-668-2454 / f: 919-668-2458 / e: bean0010@mc.duke.edu
  • "Can the Presence of Methylation of the Retinonic Acid Receptor-beta2 P2 Promoter in Random Periareolar Fine Needle Aspiration be Used to Risk-stratify Women at Risk for Breast Cancer?"
    Abstract / Video
• Hans Bjornsson — Predoctoral Program in Human Genetics, Johns Hopkins University School of Medicine
  720 Rutland Avenue; Baltimore, MD 21205; United States • p: 410-614-4499 / f: 410-614-9819 / e: hbjorns1@jhmi.edu
  • "Could Epigenome Degeneration be a Cause for the Late Onset of Complex Disease Phenotypes?"
    Abstract / Video
• Francisco Cisneros — Preclinical Services, Charles River Laboratories
  905 Sheehy Dr # A; Horsham, PA 19044; United States • p: 215-443-2277 / f: 215-443-8039 / e: fjcisner@yahoo.com
  • "Altered DNA Methylation Induced In Utero May Cause Multigenerational Abnormal Development: Role of Epigenetic Inheritance"
    Abstract / Video
• James Curley — Sub-Department of Animal Behaviour, University of Cambridge
  High Street Madingley; Cambridge CB3 8AA; United Kingdom • p: +4401223741812 / f: +4401223741802 / e: jamescurley77@yahoo.co.uk
  • "Parent-of-origin Effects on Behavior and Development in Reciprocal Hybrid Mice"
    Abstract / Video
• Tomas Ekstrom — Department of Clinical Neuroscience, Karolinska Institutet
  Building L8:01; Stockholm SE-17176; Sweden • p: +46851774634 / f: +46851774615 / e: tomas.ekstrom@cmm.ki.se
  • "LUMA - A High Throughput Method to the Assessment of Global Genomic DNA Methylation"
    Abstract / Video
• Rosalind John — School of Biosciences, Cardiff University
  Museum Avenue; Cardiff CF10 3US; United Kingdom • p: +44 (0)29 20 870145 / f: +44 (0)29 20 874116 / e: JohnRM@cardiff.ac.uk
  • "Two Physically and Mechanistically Linked Imprinted Genes, Cdkn1c and Phlda2, Act in Parallel to Regulate Embryonic and Extra-Embryonic Growth"
    Abstract / Video
• Sarah Lewis — Department of Social Medicine, University of Bristol
  Canynge Hall, Whiteladies Road; Bristol BS8 2PR; United Kingdom • p: 00441179287266 / f: 00441173313914 / e: s.j.lewis@bristol.ac.uk
  • "Does Maternal MTHFR C677T Genotype Influence Subsequent Schizophrenia Risk Via Epigenetic Mechanisms?"
    Abstract / Video
• Philippe Luedi — Center for Bioinformatics and Computational Biology, Duke University Medical Center
  Research Drive; Durham, NC 27710; United States • p: 919-684-3224 / f: 919-684-3224 / e: ppl@duke.edu
  • "Genome-wide Prediction of Imprinted Murine Genes"
    Abstract / Video
• Riyaz Mahammad — Department of Biomedical Sciences, University of Rhode Island
  41 Lower College Road; Kingston, RI 02881; United States • p: 401-874-5368 / f: 401-874-2516 / e: riyaz@uri.edu
  • "Fetal Pb-exposure and Neurodegeneration in Aging Brains"
    Abstract / Video
• Carmen Sapienza — Fels Institute for Cancer Research, Temple University Medical School
  3307 North Broad Street; Philadelphia, PA 19140; United States • p: 215-707-7373 / f: 215-707-1454 / e: sapienza@temple.edu
  • "Human Imprinted Chromosomal Regions are Historical Hot-Spots of Recombination"
    Abstract / Video
• Sue Varmuza — Department of Zoology, University of Toronto
  25 Harbord Street; Toronto M5S 3G5; Canada • p: 416-978-2759 / f: 416-978-8532 / e: svarmuza@zoo.utoronto.ca
  • "Parthenogenetic Embryos are Defective in Stem Cell Establishment"
    Abstract / Video
• Paula Vertino — Winship Cancer Institute, Emory University School of Medicine
  1365-C Clifton Road; Atlanta, GA 30322; United States • p: 404-778-3119 / f: 404-778-5530 / e: pvertin@emory.edu
  • "Identifying Sequence Features that Contribute to the Risk of Aberrant DNA Methylation in Cancer"
    Abstract / Video
• xx-PANEL DISCUSSION-xx — Moderators , Terry Graedon and Joe Graedon - People's Pharmacy
  Washington Duke Inn; Durham, NC; United States • e: jirtle@radonc.duke.edu
  • "Andy Feinberg, Jerry Heindel, John McLachlan, Adele Murrell, Marcus Pembrey, Fred Tyson, Emma Whitelaw"
    Abstract / Video

Conference Sponsors

National Institute of Environmental Health Sciences • Duke Comprehensive Cancer Center • Duke Department of Radiation Oncology • Duke University Integrated Toxicology Program • Duke University Superfund Basic Research Center • Rete Mirabile Fund of the Triangle Community Foundation • Elsevier's Advances in Developmental Biology • Sumitomo Chemical Company • Merck Research Laboratories • OncoMethylome Sciences • Roche Applied Science • Amplicon Express • GlaxoSmithKline • AstraZeneca • Diagenode