2005: Environmental Epigenomics, Imprinting and Disease Susceptibility
Durham, NC: The 'early origins hypothesis' of Barker states that environmental factors, such as nutrition acting in early life, program the risks for adverse health outcomes in adult life. This hypothesis is now supported by a number of epidemiological studies performed worldwide. Environmental perturbations during gestation are also known to affect adult phenotype by altering gene expression through the modification of DNAÂ methylation and chromatin structure. The objective of this conference is to discuss the evidence that genomic elements, such as transposons and imprinted genes, can function as epigenetically labile targets for linking environmental exposures during early development to adult susceptibility of developing medical conditions such as asthma, cancer, behavioral disorders, cardiovascular disease, diabetes, and obesity.
ORGANIZERS: Randy L. Jirtle (Duke University) and Fred Tyson (NIEHS)
Invited Speaker Presentations
The following is a list of the Environmental Epigenomics conference speakers and their addresses, along with links to their presentation abstracts and recordings.
- Trevor Archer — Laboratory of Molecular Carcinogenesis, NIEHS
PO Box 12233; Research Triangle Park, NC 27709; United States • p: +1 919-316-4565 / f: +1 919-316-4566 / e: archer1@niehs.nih.gov - Marisa Bartolomei — Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine
363 Clinical Research Building, 415 Curie Boulevard; Philadelphia, PA 19104; United States • p: +1 215-898-9063 / f: +1 215-573-6434 / e: bartolom@mail.med.upenn.edu - Manel Esteller — Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO)
Melchor Fernandez Almagro 3; Madrid 28029; Spain • p: +34 91-2246940 / f: +34 91-2246923 / e: mesteller@cnio.es - Andrew Feinberg — Department of Medicine, Molecular Biology and Genetics, and Oncology, Johns Hopkins University School of Medicine
Ross Building 1064, 720 Rutland Ave.; Baltimore, MD 21205; United States • p: +1 410-614-3489 / f: +1 410-614-9819 / e: afeinberg@jhu.edu - David Haig — Department of Organismic and Evolutionary Biology, Harvard University
26 Oxford Street; Cambridge, MA 02138; United States • p: +1 617-496-5125 / f: +1 617-495-5667 / e: dhaig@oeb.harvard.edu - Andrew Hoffman — Department of Medicine, Stanford University
Palo Alto, CA 94304; United States • p: 650-858-3930 / f: 650-856-8024 / e: arhoffman@stanford.edu - Jean-Pierre Issa — Department of Leukemia, M.D. Anderson Cancer Center
Unit 425, 1515 Holcombe Street; Houston, TX 77030; United States • p: 914-351-2368 / f: 914-351-2118 / e: jpissa@mail.mdanderson.org - Randy Jirtle — Department of Oncology, University of Wisconsin-Madison
Durham, NC 27710; United States • p: 919-684-2770 / f: 919-684-5584 / e: jirtle@radonc.duke.edu - Joanne Kurtzberg — Department of Pediatrics - Bone Marrow Program, Duke University Medical Center
Durham, NC 27710 ; United States • p: 919-668-1100 / f: 919-668-1183 / e: kurtz001@mc.duke.edu - Jeannie Lee — Howard Hughes Medical Institute, Department of Genetics , Harvard Medical School
Boston, ME; United States • p: 617-726-5943 / f: 617-726-6893 / e: lee@frodo.mgh.harvard.edu - Haifan Lin — Department of Cell Biology, Duke University Medical Center
Durham, NC 27710 ; United States • p: 919-684-3169 / f: 919-684-5481 / e: h.lin@cellbio.duke.edu - Victor Lobanenkov — Section of Molecular Pathology, Laboratory of Immunopathology, National Institutes of Health
Twinbrook I Building, 5640 Fishers Lane ; Rockville, MD 20852; United States • p: 301-435-1690 / f: 301-402-0077 / e: vlobanenkov@niaid.nih.gov - John McLachlan — Center for Bioenvironmental Research, Tulane and Xavier Universities
New Orleans, LA 70112 ; United States • p: 504-988-6910 / f: 504-988-6428 / e: john.mclachlan@tulane.edu - Adele Murrell — Senior Cancer Research Fellow, Hutchison/MRC Research Centre, Department of Oncology, University of Cambridge
Hills Road; Cambridge CB2 2XZ; United Kingdom • p: 01223-763377 / f: 01223-763262 / e: amm207@cam.ac.uk - Marcus Pembrey — Institute of Child Health, UCL
Picketts South, Picketts Lane; Redhill RH1 5RG; United Kingdom • p: +44-1293-771-202 / f: +44-1293-771-202 / e: M.Pembrey@bristol.ac.uk - Jorge Piedrahita — United States
- Bruce Richardson — Department of Medicine, University of Michigan
5310 Cancer Center and Geriatrics Center; Ann Arbor, MI 48109-0940; United States • p: 734-763-6940 / f: 734-936-9220 / e: Brichard@umich.edu - Douglas Ruden — Department of Environmental Health Sciences, University of Alabama at Birmingham
530 Ryals Public Health Building, 1665 University Boulevard; Birmingham, AL 35294-0022; United States • p: 205-934-7042 / f: 205-934-7142 / e: douglasr@uab.edu - Gerald Schatten — Departments of Obstetrics , University of Pittsburgh School of Medicine
204 Craft Avenue ; Pittsburgh, PA 15213; United States • p: 412-641-2400 / f: 412-641-2410 / e: gschatten@pdc.magee.edu - David Schwartz — University of Colorado
12631 E 17th Ave; Aurora, CO 80045; United States • e: david.schwatrz@ucdenver.edu - David Skuse — Behavioural and Brain Sciences Unit, Institute of Child Health
30 Guilford Street ; London WC1N 1EH ; United Kingdom • p: +44-207-831-0975 / f: +44-207-831-7050 / e: dskuse@ich.ucl.ac.uk - Moshe Szyf — Department of Pharmacology and Therapeutics , McGill University
3655 Sir William Osler Promenade, McGill University ; Montreal, Quebec H3G 1Y6; Canada • p: 514-398-7107 / f: 514-398-6690 / e: mszyf@pharma.mcgill.ca - Donata Vercelli — College of Medicine , University of Arizona
1501 North Campbell Avenue, Suite 2349; Tucson, AZ 85724-5030 ; United States • p: 520-626-6387 / f: 520-626-6970 / e: donata@resp-sci.arizona.edu - Paul Wade — Laboratory of Molecular Carcinogenesis , NIEHS
Research Triangle Park; , NC 27709 ; United States • p: 919-541-3392 / f: 919-541-0146 / e: wadep2@niehs.nih.gov - Robert Waterland — Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, Children's Nutrition Research Center
1100 Bates St., Rm. 9070 ; Houston, TX 77030 ; United States • p: 713-798-0304 / f: 713-798-7171 / e: waterland@bcm.tmc.edu - Emma Whitelaw — School of Molecular and Microbial Biosciences, University of Sydney
Biochemistry Building, Butlin Avenue; New South Wales 2006; Australia • p: +61-2-9351-2549 / f: +61-2-9351-4726 / e: e.whitelaw@mmb.usyd.edu.au
Attendee Presentations
- Gregory Bean — Division of Medical Oncology, Duke University Medical Center
Box 2628, Room 221A, MSRB; Durham, NC 27710; United States • p: 919-668-2454 / f: 919-668-2458 / e: bean0010@mc.duke.edu - Hans Bjornsson — Predoctoral Program in Human Genetics, Johns Hopkins University School of Medicine
720 Rutland Avenue; Baltimore, MD 21205; United States • p: 410-614-4499 / f: 410-614-9819 / e: hbjorns1@jhmi.edu - Francisco Cisneros — Preclinical Services, Charles River Laboratories
905 Sheehy Dr # A; Horsham, PA 19044; United States • p: 215-443-2277 / f: 215-443-8039 / e: fjcisner@yahoo.com - James Curley — Sub-Department of Animal Behaviour, University of Cambridge
High Street Madingley; Cambridge CB3 8AA; United Kingdom • p: +4401223741812 / f: +4401223741802 / e: jamescurley77@yahoo.co.uk - Tomas Ekstrom — Department of Clinical Neuroscience, Karolinska Institutet
Building L8:01; Stockholm SE-17176; Sweden • p: +46851774634 / f: +46851774615 / e: tomas.ekstrom@cmm.ki.se - Rosalind John — School of Biosciences, Cardiff University
Museum Avenue; Cardiff CF10 3US; United Kingdom • p: +44 (0)29 20 870145 / f: +44 (0)29 20 874116 / e: JohnRM@cardiff.ac.uk - Sarah Lewis — Department of Social Medicine, University of Bristol
Canynge Hall, Whiteladies Road; Bristol BS8 2PR; United Kingdom • p: 00441179287266 / f: 00441173313914 / e: s.j.lewis@bristol.ac.uk - Philippe Luedi — Center for Bioinformatics and Computational Biology, Duke University Medical Center
Research Drive; Durham, NC 27710; United States • p: 919-684-3224 / f: 919-684-3224 / e: ppl@duke.edu - Riyaz Mahammad — Department of Biomedical Sciences, University of Rhode Island
41 Lower College Road; Kingston, RI 02881; United States • p: 401-874-5368 / f: 401-874-2516 / e: riyaz@uri.edu - Carmen Sapienza — Fels Institute for Cancer Research, Temple University Medical School
3307 North Broad Street; Philadelphia, PA 19140; United States • p: 215-707-7373 / f: 215-707-1454 / e: sapienza@temple.edu - Sue Varmuza — Department of Zoology, University of Toronto
25 Harbord Street; Toronto M5S 3G5; Canada • p: 416-978-2759 / f: 416-978-8532 / e: svarmuza@zoo.utoronto.ca - Paula Vertino — Winship Cancer Institute, Emory University School of Medicine
1365-C Clifton Road; Atlanta, GA 30322; United States • p: 404-778-3119 / f: 404-778-5530 / e: pvertin@emory.edu - xx-PANEL DISCUSSION-xx — Moderators , Terry Graedon and Joe Graedon - People's Pharmacy
Washington Duke Inn; Durham, NC; United States • e: jirtle@radonc.duke.edu
Conference Sponsors
National Institute of Environmental Health Sciences • Duke Comprehensive Cancer Center • Duke Department of Radiation Oncology • Duke University Integrated Toxicology Program • Duke University Superfund Basic Research Center • Rete Mirabile Fund of the Triangle Community Foundation • Elsevier's Advances in Developmental Biology • Sumitomo Chemical Company • Merck Research Laboratories • OncoMethylome Sciences • Roche Applied Science • Amplicon Express • GlaxoSmithKline • AstraZeneca • Diagenode