Imprinting Articles : Cancer

Below are selected articles on genomic imprinting organized by subject. Select a subject by clicking its tab. Hover over each article's title to view its abstract, and click the title to view its full PubMed record. Corresponding authors follow the author list, and fulltext PDFs are available for some articles and reviews.

• Imprinted Genes
• Regulation
• Cancer
• Developmental Disorders
• Fetal Origins of Disease
• Epigenetics
• Evolution

• Review: Human imprinting disorders: Principles, practice, problems and progress
  Mackay DJG, Temple IK
  Eur J Med Genet 60:618-626 (2017)
• Monoallelic Gene Expression in Mammals
  Chess A
  Annu Rev Genet 50:317-327 (2016)
• Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues
  Krautkramer KA, Kreznar JH, Romano KA, Vivas EI, Barrett-Wilt GA, Rabaglia ME, Keller MP, Attie AD, Rey FE, Denu JM
  Mol Cell 64:982-992 (2016)
  → Feature Article and Press Reports
• Loss of insulin-like growth factor II imprinting is a hallmark associated with enhanced chemo/radiotherapy resistance in cancer stem cells
  Zhao X, Liu X, Wang G, Wen X, Zhang X, Hoffman AR, Li W, Hu JF, Cui J
  Oncotarget (Jun 2016)
• Gliomas Genomics and Epigenomics: Arriving at the Start and Knowing It for the First Time
  Filbin MG, Suva ML
  Annu Rev Pathol 11:497-521 (2016)
• Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain
  Perez JD, Rubinstein ND, Fernandez DE, Santoro SW, Needleman LA, Ho-Shing O, Choi JJ, Zirlinger M, Chen SK, Liu JS, Dulac C
  Elife 4: (2015)
• Maternal-fetal conflict, genomic imprinting and mammalian vulnerabilities to cancer
  Haig D
  Philos Trans R Soc Lond B Biol Sci 370: (2015)
• A systems-level approach to parental genomic imprinting: the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation
  Al Adhami H, Evano B, Le Digarcher A, Gueydan C, Dubois E, Parrinello H, Dantec C, Bouschet T, Varrault A, Journot L
  Genome Res 25:353-67 (2015)
• Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes
  Madon-Simon M, Cowley M, Garfield AS, Moorwood K, Bauer SR, Ward A
  BMC Biol 12:771 (2014)
  → Feature Article and Press Reports
• Recurrent epimutation of SDHC in gastrointestinal stromal tumors
  Killian JK, Miettinen M, Walker RL, Wang Y, Zhu YJ, Waterfall JJ, Noyes N, Retnakumar P, Yang Z, Smith WI, Killian MS, Lau CC, Pineda M, Walling J, Stevenson H, Smith C, Wang Z, Lasota J, Kim SY, Boikos SA, Helman LJ, Meltzer PS
  Sci Transl Med 6:268ra177 (2014)
• Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice
  Yu DH, Waterland RA, Zhang P, Schady D, Chen MH, Guan Y, Gadkari M, Shen L [L Shen]
  J Clin Invest 124:3708-12 (2014)
  → Feature Article and Press Reports
• Review: Dawning of the epigenetic era in hereditary cancer
  Hitchins MP, Lynch HT
  Clin Genet (Mar 2014)
• Review: Genomic imprinting: sensing the environment and driving the fetal growth
  Lambertini L
  Curr Opin Pediatr (Feb 2014)
• Beckwith-Wiedemann and Silver-Russell syndromes: opposite developmental imbalances in imprinted regulators of placental function and embryonic growth
  Jacob K, Robinson W, Lefebvre L
  Clin Genet 84:326-34 (2013)
• Environmental Epigenomics in Health and Disease
  Jirtle RL, Tyson FL
  Springer (May 2013)
  → Feature Article and Press Reports
• A nucleolar protein, H19 opposite tumor suppressor (HOTS), is a tumor growth inhibitor encoded by a human imprinted H19 antisense transcript
  Onyango P, Feinberg AP
  Proc Natl Acad Sci U S A 108:16759-64 (2011)
• A role for the elongator complex in zygotic paternal genome demethylation
  Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y [Yi Zhang]
  Nature 463:554-8 (2010)
• Interview Epigenomics, imprinting and disease susceptibility
  Jirtle RL [R Jirtle]
  Pharmacogenomics 9:1791-5 (2008)
  Fulltext (PDF)
• Randy L Jirtle, PhD: epigenetics a window on gene dysregulation, disease Interview by Bridget M Kuehn
  Kuehn BM
  JAMA 299:1249-250 (2008)
  Fulltext (PDF)
• Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma
  Jang HS, Kang KM, Choi BO, Chai GY, Hong SC, Ha WS, Jirtle RL
  World J Gastroenterol 14:1394-8 (2008)
  Fulltext (PDF)
• Review: Environmental epigenomics in human health and disease
  Dolinoy DC, Jirtle RL [RL Jirtle]
  Environ Mol Mutagen 49:4-8 (2008)
  Fulltext (PDF)
• Review: DNA methylation: The nuts and bolts of repression
  Miranda TB, Jones PA
  J Cell Physiol 213:384-90 (2007)
• Review: The silence of genes Is genomic imprinting the software of evolution or just a battleground for gender conflict?
  Hunter P
  EMBO Rep 8:441-3 (2007)
  Fulltext (PDF)
• Review: Imprinted and More Equal
  Jirtle RL, Weidman JR [RL Jirtle]
  Am Sci 95:143-149 (2007)
  Fulltext (PDF)→ Feature Article and Press Reports
• Review: Environmental epigenomics and disease susceptibility
  Jirtle RL, Skinner MK
  Nat Rev Genet 8:253-62 (2007)
  Fulltext (PDF)
• Review: DNA is not Destiny
  Ethan Watters
  Discover 27:32-7 (2006)
  Fulltext (PDF)
• Epigenetic silencing of genes in human colon cancer
  Liddle RA, Jirtle RL
  Gastroenterology 131:960-2 (2006)
  Fulltext (PDF)
• Review: Endocrine disruptors and reproductive health: the case of bisphenol-A
  Maffini MV, Rubin BS, Sonnenschein C, Soto AM
  Mol Cell Endocrinol 254-255:179-86 (2006)
• Review: Development of radiobiology for oncology:a personal view
  Fowler JF
  Phys Med Biol 51:R263-86 (2006)
  → Feature Article and Press Reports
• Schizophrenia, cancer and imprinting: early nutritional influences
  Abel KM, Allin MP, Jirtle RL
  Br J Psychiatry 188:394 (2006)
  Fulltext (PDF)
• Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus
  Waterland RA, Lin JR, Smith CA, Jirtle RL
  Hum Mol Genet 15:705-16 (2006)
  Fulltext (PDF)
• Review: A personal sixty-year tour of genetics and medicine
  Knudson AG
  Annu Rev Genomics Hum Genet 6:1-14 (2005)
• Review: IGF2 loss of imprinting: a potential heritable risk factor for colorectal cancer
  Jirtle RL [RL Jirtle]
  Gastroenterology 126:1190-3 (2004)
  Fulltext (PDF)
• The molecular biology of Wilms tumour
  Brown KW, Malik KT [KW Brown] [KT Malik]
  Expert Rev Mol Med 2001:1-16 (2001)
  Fulltext (PDF)
• Review: The history of cancer epigenetics
  Feinberg AP, Tycko B [AP Feinberg] [B Tycko]
  Nat Rev Cancer 4:143-53 (2004)
• Review: Imprinting evolution and the price of silence
  Murphy SK, Jirtle RL [RL Jirtle]
  Bioessays 25:577-88 (2003)
  Fulltext (PDF)→ Feature Article and Press Reports
• M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis
  Jamieson TA, Brizel DM, Killian JK, Oka Y, Jang HS, Fu X, Clough RW, Vollmer RT, Anscher MS, Jirtle RL [RL Jirtle]
  BMC Cancer 3:4 (2003)
  Fulltext (PDF)
• Loss of IGF2 imprinting: a potential marker of colorectal cancer risk
  Cui H, Cruz-Correa M, Giardiello FM, Hutcheon DF, Kafonek DR, Brandenburg S, Wu Y, He X, Powe NR, Feinberg AP [AP Feinberg]
  Science 299:1753-5 (2003)
• Review: The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer
  Klenova EM, Morse HC, Ohlsson R, Lobanenkov VV [VV Loabanenkov]
  Semin Cancer Biol 12:399-414 (2002)
• M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan
  Oka Y, Waterland RA, Killian JK, Nolan CM, Jang HS, Tohara K, Sakaguchi S, Yao T, Iwashita A, Yata Y, Takahara T, Sato S, Suzuki K, Masuda T, Jirtle RL [RL Jirtle]
  Hepatology 35:1153-63 (2002)
  Fulltext (PDF)
• An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa
  Li T, Vu TH, Lee KO, Yang Y, Nguyen CV, Bui HQ, Zeng ZL, Nguyen BT, Hu JF, Murphy SK, Jirtle RL, Hoffman AR [AR Hoffman] [RL Jirtle]
  J Biol Chem 277:13518-27 (2002)
  Fulltext (PDF)
• The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q112
  Evans HK, Wylie AA, Murphy SK, Jirtle RL [RL Jirtle]
  Genomics 77:99-104 (2001)
  Fulltext (PDF)
• Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations
  Killian JK, Oka Y, Jang HS, Fu X, Waterland RA, Sohda T, Sakaguchi S, Jirtle RL [RL Jirtle]
  Hum Mutat 18:25-31 (2001)
  Fulltext (PDF)
• Review: Genomic imprinting: parental influence on the genome
  Reik W, Walter J [W Reik] [J Walter]
  Nat Rev Genet 2:21-32 (2001)
• Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis
  Motyka B, Korbutt G, Pinkoski MJ, Heibein JA, Caputo A, Hobman M, Barry M, Shostak I, Sawchuk T, Holmes CF, Gauldie J, Bleackley RC [RC Bleackley]
  Cell 103:491-500 (2000)
• Review: Imprinted genes as potential genetic and epigenetic toxicologic targets
  Murphy SK, Jirtle RL
  Environ Health Perspect 108 Suppl 1:5-11 (2000)
  Fulltext (PDF)
• Review: Genomic imprinting and cancer
  Jirtle RL [RL Jirtle]
  Exp Cell Res 248:18-24 (1999)
  Fulltext (PDF)
• Review: Genomic imprinting: implications for human disease
  Falls JG, Pulford DJ, Wylie AA, Jirtle RL [RL Jirtle]
  Am J Pathol 154:635-47 (1999)
  Fulltext (PDF)
• NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas
  Yu Y, Xu F, Peng H, Fang X, Zhao S, Li Y, Cuevas B, Kuo WL, Gray JW, Siciliano M, Mills GB, Bast RC [RC Bast]
  Proc Natl Acad Sci U S A 96:214-9 (1999)
• Review: Polymorphisms, genomic imprinting and cancer susceptibility
  Pulford DJ, Falls JG, Killian JK, Jirtle RL [RL Jirtle]
  Mutat Res 436:59-67 (1999)
  Fulltext (PDF)
• Imprinted M6p/Igf2 receptor is mutated in rat liver tumors
  Mills JJ, Falls JG, De Souza AT, Jirtle RL
  Oncogene 16:2797-802 (1998)
  Fulltext (PDF)
• Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis
  Yamada T, De Souza AT, Finkelstein S, Jirtle RL [RL Jirtle]
  Proc Natl Acad Sci U S A 94:10351-5 (1997)
  Fulltext (PDF)
• Deficient transforming growth factor-beta1 activation and excessive insulin-like growth factor II (IGFII) expression in IGFII receptor-mutant tumors
  Wang S, Souza RF, Kong D, Yin J, Smolinski KN, Zou TT, Frank T, Young J, Flanders KC, Sugimura H, Abraham JM, Meltzer SJ [SJ Meltzer]
  Cancer Res 57:2543-6 (1997)
• The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum
  Ouyang H, Shiwaku HO, Hagiwara H, Miura K, Abe T, Kato Y, Ohtani H, Shiiba K, Souza RF, Meltzer SJ, Horii A [A Horii]
  Cancer Res 57:1851-4 (1997)
• Review: Imprinted genes in liver carcinogenesis
  De Souza AT, Yamada T, Mills JJ, Jirtle RL [RL Jirtle]
  FASEB J 11:60-7 (1997)
  Fulltext (PDF)
• Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours
  Souza RF, Appel R, Yin J, Wang S, Smolinski KN, Abraham JM, Zou TT, Shi YQ, Lei J, Cottrell J, Cymes K, Biden K, Simms L, Leggett B, Lynch PM, Frazier M, Powell SM, Harpaz N, Sugimura H, Young J, Meltzer SJ [SJ Meltzer]
  Nat Genet 14:255-7 (1996)
• M6P/IGF2 receptor: a candidate breast tumor suppressor gene
  Hankins GR, De Souza AT, Bentley RC, Patel MR, Marks JR, Iglehart JD, Jirtle RL [RL Jirtle]
  Oncogene 12:2003-9 (1996)
• Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels
  Mansbach JM, Mills JJ, Boyer IJ, De Souza AT, Hankins GR, Jirtle RL [RL Jirtle]
  Carcinogenesis 17:171-4 (1996)
  Fulltext (PDF)
• M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
  De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL [RL Jirtle]
  Nat Genet 11:447-9 (1995)
  Fulltext (PDF)
• Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors
  De Souza AT, Hankins GR, Washington MK, Fine RL, Orton TC, Jirtle RL [RL Jirtle]
  Oncogene 10:1725-9 (1995)
• HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
  Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin  WG
  Science 292:464-8 (2001)
  → Feature Article and Press Reports
• Cannabinoid exposure and altered DNA methylation in rat and human sperm
  Murphy SK, Itchon-Ramos N, Visco Z, Huang Z, Grenier C, Schrott R, Acharya K, Boudreau MH, Price TM, Raburn DJ, Corcoran DL, Lucas JE, Mitchell JT, McClernon FJ, Cauley M, Hall BJ, Levin ED, Kollins SH
  Epigenetics (Dec 2018)
• Review: Genomic imprinting disorders: lessons on how genome, epigenome and environment interact
  Monk D, Mackay DJG, Eggermann T, Maher ER, Riccio A
  Nat Rev Genet (Jan 2019)
• Review: Paediatrician's guide to epigenetics
  Byrne L, Drake AJ
  Arch Dis Child (Jan 2019)
• Review: The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility
  Skaar DA, Li Y, Bernal AJ, Hoyo C, Murphy SK, Jirtle RL
  ILAR J 53:341-58 (2012)
  → Feature Article and Press Reports
• Epigenetic Dysregulation of Imprinting and Triple-Negative Breast Cancer
  Skaar DA, Dietze EC, Alva-Ornelas JA, Ann D, Schones DE, Hyslop T, Sistrunk C, Zalles C, Ambrose A, Kennedy K, Idassi O, Miranda Carboni G, Gould MN, Jirtle RL, Seewaldt VL
  Cancers (Basel) 13: (2021)
  → Feature Article and Press Reports
• Review: Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action
  Yamada T
  Toxicol Res (Camb) 7:681-696 (2018)
• CRISPR/Cas mediated epigenome editing for cancer therapy
  Ansari I, Chaturvedi A, Chitkara D, Singh S
  Semin Cancer Biol 83:570-583 (2022)
• Genomic map of candidate human imprint control regions: the imprintome
  Jima DD, Skaar DA, Planchart A, Motsinger-Reif A, Cevik SE, Park SS, Cowley M, Wright F, House J, Liu A, Jirtle RL, Hoyo C
  Epigenetics (Jul 2022)
  → Feature Article and Press Reports
• Review: Toxicoepigenetics and Environmental Health: Challenges and Opportunities
  Svoboda LK, Perera BPU, Morgan RK, Polemi KM, Pan J, Dolinoy DC
  Chem Res Toxicol 35:1293-1311 (2022)

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