Education
Virginia Polytechnic Institute and State University, Blacksburg, VA, BS, Physics, 1987.
Cornell University, Ithaca, NY, PhD, Human Nutrition, 2000.
Employment
Research Assistant, Virginia Polytechnic Institute and State University Department of Physics, Blacksburg, VA, 1984 - 1986.
Instrumentation Specialist, University of Pennsylvania Department of Biochemistry and Biophysics, Philadelphia, PA, 1987 - 1990.
Health Physics Technician, Bartlett Nuclear, Inc., Salem, NJ, 1990.
Sales Engineer, General Energy Tech, Inc., West Chester, PA, 1991 - 1993.
Senior Research Coordinator, University of Pennsylvania Department of Psychiatry, Philadelphia, PA, 1993 - 1995.
Dannon Institute Postdoctoral Fellow in Nutrition Science, Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 2000 - 2002.
Postdoctoral Fellow, Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 2000 - 2004.
Assistant Professor, Department of Pediatrics, Baylor Medical Center, Houston, TX, 2004-present.
Professional Societies
American Society for Nutritional Sciences
American Society for Clinical Nutrition
American Society for Biochemistry and Molecular Biology
International Society for the Developmental Origins of Health and Disease
Fellowships and Awards
NIH Predoctoral Traineeship, Human Nutrition, Cornell University 1996 - 1999.
Hooker Huntington Fellowship, Cornell University, 1997 - 1998.
Steininger Fellowship, Cornell University, 1997 - 1998.
Berens Fellowship, Cornell University, 1998 - 1999.
Werly Fellowship, Cornell University, 1999.
Prescott Fellowship, Cornell University, 1999.
Postdoctoral Fellowship in Interdisciplinary Nutrition Science, Dannon Institute,
September 2000 - 2002.
CTM award, Toastmasters International, June, 2002.
Invited Seminars
"Potential for metabolic imprinting by nutritional perturbation of epigenetic gene regulation." Presented at the 48th Nestle Nutrition Workshop: Public Health Issues in Infant and Child Nutrition, St. Petersburg, Russia, September, 2000.
"Early origins of adult chronic disease: potential biologic mechanisms." Presented at the 35th annual conference of the Society for Nutrition Education: Advancing WomenÕs Health for Healthy Communities, St. Paul, Minnesota, July, 2002.
"Early origins of adult chronic disease: human epidemiology and potential biologic mechanisms." Presented at the Texas Department of Health WIC Nutrition and Breastfeeding Conference, Austin, Texas, April, 2003.
"Toxic food? Early nutritional influences on epigenetic gene regulation." Presented to the Dept. of Molecular Toxicology, AstraZeneca, Alderley Park, UK, June 2003.
University Service
President, Nutrition Graduate Student Organization, Cornell University, 1996-1999.
Student Representative, Nutritional Sciences Animal Welfare Committee, Cornell University, 1999-2000.
Co-Founder, Duke University Postdoctoral Association, 2001.
President, Duke University Postdoctoral Association, 2002 - 2003.
Guest Lectures
Nutritional Sciences 614: Maternal and Child Nutrition: "Obesity in Infancy and Childhood", 1996 - 1999.
Nutritional Sciences 222: Maternal and Infant Nutrition: "Metabolic Imprinting", 1997.
Human Services Studies 330: Ecology and epidemiology of health: "Population based public health interventions", 1997.
Nutritional Sciences 614: Maternal and Child Nutrition: "The Barker Hypothesis", 1998, 1999.
Nutritional Sciences 400: Molecular epidemiology and dietary markers of chronic disease: "Gene-nutrient interactions in mammalian development", 2000.
Grants Awarded
"Metabolic imprinting of glucose-6-phosphate dehydrogenase in rat liver." Cornell University Division of Nutritional Sciences Research Committee, ($1,500), May, 1996.
"Mechanisms underlying the persistent effects of suckling-period litter size on insulin axis development in the rat." Cornell University Division of Nutritional Sciences Research Committee, ($1,500), February, 1998.
"Mechanisms underlying the persistent effects of suckling-period litter size on pancreatic insulin secretion in rats." Cornell University Division of Nutritional Sciences Research Committee, ($750), January, 1999.
"Nutritional influences on epigenetic regulation of gene expression at genomically-imprinted loci." Dannon Institute, ($74,000), September, 2000.
"Early nutritional influences on mammalian cancer epigenetics." Duke University Comprehensive Cancer Center, ($4,000), October 2002.
"Early nutritional influences on mammalian cancer epigenetics." American Cancer Society, ($85,000), July 2003.
"Early nutritional influences on mammalian epigenetics." NIDDK, ($149,900), August, 2003.
Publications
1. Chance, B., Waterland RA, Tanaka, A., and Poyton, R.O. Mitochondrial function in normal and genetically altered cells and tissues. Ann. NY Acad. Sci. 550: 360-373, 1988.
2. Waterland RA, Basu, A., Chance, B., and Poyton, R.O. The isoforms of yeast cytochrome oxidase subunit V alter the in vivo kinetic properties of the holoenzyme. J. Biol. Chem. 266: 4180-4186, 1991.
3. Basu, A., Waterland RA, and Chance, B. Kinetics of ligand binding of cytochrome oxidases: a comparative study. Biochim. Biophys. Acta 1184: 291-295, 1994.
4. Waterland RA, Berkowitz, R.I., Stunkard, A.J., Stallings, V.A. Calibrated-orifice nipples for the measurement of infant nutritive sucking. J. Pediatr. 132: 523-526, 1998.
5. Waterland RA, and Garza, C. Potential mechanisms of metabolic imprinting that lead to chronic disease. Am. J. Clin. Nutr. 69: 179-197, 1999.
6. Killian, J.K., Oka, Y., Jang H.-S., Fu, X., Waterland RA, Sohda, T., Sakaguchi, S., and Jirtle, R.L. Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations. Hum. Mutat. 18: 25-31, 2001. [PDF]
7. Oka, Y., Waterland RA, Killian, J.K., Nolan, C.M., Jang, H.S., Tohara, K., Sakaguchi, S., Yao, T., Iwashita, A., Yata, Y., Takahara, T., Sato, S.I., Suzuki, K., Masuda, T., and Jirtle, R.L. M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan. Hepatology 35: 1153-1163, 2002. [PDF]
8. Waterland RA, and Garza, C. Early postnatal nutrition determines adult pancreatic glucose-responsive insulin secretion and islet gene expression in rats. J. Nutr. 132: 357-364, 2002. [PDF]
9. Wylie, A.A., Pulford, D.J., McVie-Wylie, A.J., Waterland RA, Evans, H.K., Chen, Y.T., Nolan, C.M., Orton, T.C., and Jirtle, R.L. Tissue-specific inactivation of murine M6P/IGF2R.Am. J. Pathol. 162: 321-328, 2003. [Commentary] [PDF]
10. Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 23: 5293-5300, 2003. [Journal Cover][PDF]
11. Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20: 63-68, 2004 [PDF]
Book Chapters
1. Stunkard, A.J., and Waterland RA The three-factor eating questionnaire Š eating inventory. In: St. Joer ST, ed. Obesity Assessment - tools, Methods,Iinterpretations. New York: Chapman & Hall, pp. 343-341, 1997.
2. Waterland RA, and Garza G. Potential for metabolic imprinting by nutritional perturbation of epigenetic gene regulation. In: Black R, Michaelson KF, eds. Infant Nutrition and Public Health. Proceedings of the 48th Nestle Nutrition Workshop, 317-333, 2002.
3. Waterland RA Metabolic imprinting and programming. In: Katz SH, ed. The Encyclopedia of Food. New York: Charles Scribner's Sons, 2003.
Abstracts
1. Waterland RA, Powers, L., Chance, B., and Poyton, R.O. Effects of subunits 5a, 5b on yeast cytochrome oxidase. FASEB J. 2: 774a, 1988.
2. Chance, B., Powers, L., Poyton, R.O., and Waterland RA Subunit control of cytochrome oxidase. Biophys. J. 53: 373a, 1988.
3. Basu, A., Waterland RA, Poyton, R.O., and Chance, B. Influence of nuclear coded subunits on cytochrome c oxidase activity. Biophys. J. 55: 567a, 1989.
4. Chance, B., Poyton, R.O., Basu, A., Waterland RA Expression of cytochrome oxidase and hemoglobin in saccharomyces cerevisiae mutants. J. Cell Biol. 107: 345a, 1989.
5. Waterland RA, Basu, A., Poyton, R.O., and Chance, B. Enhanced internal electron transfer within the subunit 5b isozyme of yeast cytochrome oxidase. Biophys. J. 57: 232a, 1990.
6. Maragos, C., Waterland RA,Stallings, V.A., Berkowitz, R.I., and Stunkard, A.J. Energy intake of infants born to lean and obese mothers. Presented at the Beltsville symposium on human energy requirements, Beltsville, MD, 1994.
7. Berkowitz, R.I., Stallings, V.A., Waterland RA, Maragos, C., Boardman, C., and Stunkard, A.J. Body composition of infants born to lean and obese mothers. Intl. J. Obes. 18: S2, 1994.
8. Stallings, VA., Berkowitz, R.I., Maragos, C., Waterland RA, Boardman, C., and Stunkard, A.J. Resting energy expenditure of infants born to lean and obese mothers. Intl. J. Obes. 18: S2, 1994.
9. Waterland RA, Berkowitz, R.I., Stallings, V.A., Maragos, C., Tanrikut, C., Boardman, C., and Stunkard, A.J. Growth and body composition of infants at low and high risk for obesity. Intl. J. Obes. 19: S2:O74, 1995.
10. Berkowitz, R.I., Stallings, V.A., Waterland RA, Maragos, C., Tanrikut, C., Boardman, C., and Stunkard, A.J. Feeding style of infants at low and high risk for obesity. Intl. J. Obes. 19: S2:O75, 1995.
11. Waterland RA,and Garza, C.. Metabolic imprinting of insulin responses initiated by early postnatal undernutrition. FASEB J. 13: A375, 1999.
12. Waterland RA, and Garza, C. Global gene expression and putative metabolic imprinting in the endocrine pancreas. Oral presentation at the American Society for Biochemistry and Molecular Biology Symposium "Nutritional Control of Gene Transcription", Taos, NM, 1999.
13. Waterland RA, and Garza, C. Global gene expression and putative metabolic imprinting in the endocrine pancreas. FASEB J., 2000.
14. Waterland RA, Jirtle RL. Maternal dietary methyl donor supplementation affects offspring phenotype by increasing cytosine methylation at the agouti locus in Avy mice. FASEB J. 16: A233, 2002.
15. Waterland RA, Perry CA, Stover PJ, Jirtle RL. Dietary methyl donor deficiency in late gestation causes DNA hypermethylation in newborn mouse liver. FASEB J. 16: A228, 2002.
16. Waterland RA, Jirtle RL. Developmental relaxation of insulin-like growth factor 2 imprinting in kidney is determined by weanling diet. Ped. Res. 53 (Suppl. 5A): 2003.
17. Dolinoy, D.C., Weidman, J.R., Waterland, R.A., and Jirtle, R.L. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ. Health Perspect. 14: 567-572, 2006.
18. Waterland, R.A., Lin, J.-R., Smith, C.A., and Jirtle, R.L. Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum. Mol. Genet. 15: 705-716, 2006.