Articles from 1971-1979

1. Jirtle RL, and Clifton, K.H. On carcinoma growth and vascular supply: A study of mouse mammary tumor strain MTG-B. Proc. Soc. Exp. Biol. & Med. 138: 267-269, 1971.

2. Jirtle RL, and Clifton, K.H. Effect of preirradiation of the tumor bed on the relative vascular space of mouse gastric adenocarcinoma 328 and mammary adenocarcinoma CA755. Cancer Res. 33: 764-768, 1973.

3. Clifton, K.H. and Jirtle RL. Mammary carcinoma cell population growth in preirradiated and unirradiated transplant sites. Radiology 117: 459-465, 1975.

4. Thesis for Doctor of Philosophy degree, University of Wisconsin-Madison, 1976, "Cellular Radiation Response as a Function of Tumor Size, Host Hematocrit, and Erythrokinetics in CA755 Tumor-Bearing Mice" (Referred by Thesis Review Committee: Clifton, K.H., Caldwell, W., Durand, R., Klotz, J. and Lane, R.).

5. Hankin, J.H.G., Jirtle RL, and Phernetton, T.M. Anomalous responses of tumor vasculature to norepinephrine and prostaglandin E2 in the rabbit. Circulation Res. 41: 496-502, 1977.

6. Gould, M., Jirtle RL, Crowley, J., and Clifton, K.H. The number of cells involved in the neutron induction of mammary neoplasms: A reevaluation. Cancer Res. 38: 189-192, 1978.

7. Jirtle RL, and Clifton, K.H. Erythrokinetics in mice bearing tumors in either preirradiated or unrradiated tissue. Cell & Tissue Kinet. 11: 581-596, 1978.

8. Jirtle RL, and Clifton, K.H. The effect of tumor size and host anemia on cell survival after irradiation. Int. J. Rad. Oncol. Biol. Phys. 4: 395-400, 1978.

9. Jirtle RL, Clifton, K.H., and Rankin, J.H.G. Measurement of tumor blood flow in unanesthetized rats. J. Natl. Cancer Inst. 60: 881-886, 1978.

10. Jirtle RL, Clifton, K.H., and Rankin, J.H.G. Effect of several drugs on the vascular resistance of MTW-9B tumors in W/Fu rats. Cancer Res. 38: 2385-2390, 1978.

11. Jirtle RL, Rankin, J.H.G., and Clifton, K.H. Effect of X-irradiation of the tumor bed on tumor blood flow and vascular response to drugs. Br. J. Cancer 37: 1033-1038, 1978.

Articles from 1980-1984

12. Joines, W.T., Jirtle RL, Rafal, M.D., and Schaefer, D.J. Microwave power absorption differences between normal and malignant tissue. Int. J. Rad. Oncol. Biol. Phys. 6: 681-687, 1980.

13. Jirtle RL, Biles, C. and Michalopoulos, G. Morphological and histochemical analysis of hepatocytes transplanted into syngeneic hosts. Am. J. Path. 101: 115-126, 1980.

14. Jirtle RL. Blood flow to lymphatic metastases in conscious rats. Eur. J. Cancer 17: 53-60, 1981.

15. Jirtle RL, and Hinshaw, W.M. Estimation of malignant tissue blood flow with radioactively labelled microspheres. Eur. J. Cancer Clin. Oncol. 17: 1353-1355, 1981.

16. Jirtle RL, Michalopoulos, G., McLain, J.R., and Crowley, J. The survival of parenchymal hepatocytes exposed to ionizing radiation. Cancer Res. 41: 3512-3518, 1981.

17. Strom, S.C., Jirtle RL, Jones, R.S., Rosenberg, M.R., and Michalopoulos, G. Isolation, culture and transplantation of human hepatocytes. J. Natl. Cancer Inst. 68: 771-778, 1982.

18. Novicki, D.L., Strom, S.C., Jirtle RL, and Michalopoulos, G. Cryopreservation of isolated rat hepatocytes. In Vitro 18: 393-399, 1982.

19. Jirtle RL, and Michalopoulos, G. Effects of partial hepatectomy on transplanted hepatocytes. Cancer Res. 42: 3000-3004, 1982.

20. Jirtle RL, McLain, J.R., Strom, S.C,. and Michalopoulos, G. Repair of radiation damage in noncycling parenchymal hepatocytes. Br. J. Radiol. 55: 847-851, 1982.

21. Kaelin, W.G., Jr., Shrivastav, S., Shand, D.G., and Jirtle RL. Effect of verapamil on malignant tissue blood flow in SMT-2A tumor bearing rats. Cancer Res. 42: 3944-3949, 1982.

22. Michalopoulos, G., Jirtle RL, Kligerman, A.D., Cianciulli, D., and Novotny, A. Liver regeneration studies in primary culture of hepatocytes Cancer Res. 42: 4673-4682, 1982.

23. Novicki, D.L., Jirtle RL, and Michalopoulos, G. Establishment of two rat hepatoma cell strains produced by a carcinogen initiation, phenobarbital promotion protocol. In Vitro 19: 191-202, 1983.

24. Strom, S.C., Jirtle RL, and Michalopoulos, G. Genotoxic effects of 2-acetylamino-fluorene on rat and human hepatocytes. Envir. Health Perspect. 49: 165-170, 1983.

25. Strom, S.C., Novicki, D.L., Novotny, A., Jirtle RL, and Michalopoulos, G. Human hepatocyte-mediated mutagenesis and DNA repair activity. Carcinogenesis 4: 683-686, 1983.

26. Shrivastav, S., Kaelin, W.G., Jr., Joines, W.T., and Jirtle RL. Microwave hyperthermia and its effect on tumor blood flow. Cancer Res. 43: 4665-4669, 1983.

27. Butterworth, B.E., Earl, L.L., Strom, S.C., Jirtle RL, and Michalopoulos, G. Induction of DNA repair in human and rat hepatocytes by 1,6-dinitropyrene. Mutat. Res. 122: 73-80, 1983.

28. Gould, M.N., Cathers, L.E., Clifton, K.H., Howard, S., Jirtle RL, Mahler, P.A., Mulcahy, R.T., and Thomas, F. The influence of in situ repair systems on survival of several irradiated parenchymal cell types. Br. J. Cancer (Suppl. VI) 49: 191-196, 1984.

29. Jirtle RL, Michalopoulos, G., Strom, S.C., DeLuca, P.M., and Gould, M.N. The survival of parenchymal hepatocytes irradiated with low and high LET radiation. Br. J. Cancer (Suppl. VI) 49: 197-202, 1984.

30. Kaelin, W.G., Jr., Shrivastav, S., and Jirtle RL. Blood flow to primary tumors and lymph node metastases in SMT-2A tumor bearing rats following intravenous flunarizine. Cancer Res. 44: 896-899, 1984.

31. Jirtle RL, DeLuca, P.M., Hinshaw, W.M., and Gould, M.N. Survival of parenchymal hepatocytes irradiated with 14.3 MeV neutrons. Int. J. Radiat. Oncol. Biol. Phys. 10: 895-899, 1984.

32. Reddy, J.K., Jirtle RL, Watanabe, T.K., Reddy, N.K., Michalopoulos, G., and Qureshi, S.A. Response of hepatocytes transplanted into syngeneic hosts and heterotransplanted into athymic nude mice to peroxisome proliferators. Cancer Res. 44: 2582-2589, 1984.

33. Butterworth, B.E., Bermudez, E., Smith-Oliver, T., Earle, L., Cattley, R., Martin, J., Popp, J.A., Strom, S., Jirtle RL, and Michalopoulos, G. Lack of genotoxic activity of di(2-ethylhexyl)phthalate (DEHP) in rat and human hepatocytes. Carcinogenesis 5: 1329-1335, 1984.

Articles from 1985-1989

34. Rosenberg, M.R., Novicki, D.L., Jirtle RL, Novotny, A., and Michalopoulos, G. Promoting effect of nicotinamide on the development of renal tubular cell tumors in rats initiated with diethyl-nitrosamine. Cancer Res. 45: 809-814, 1985.

35. Bone, S.N., III, Michalopoulos, G., and Jirtle RL. The ability of partial hepatectomy to induce gamma-glutamyltranspeptidase in regenerated and transplanted hepatocytes of Fischer 344 and Wistar-Furth rats. Cancer Res. 45: 1222-1228, 1985.

36. Shrivastav, S., Joines, W.T., and Jirtle RL. Effect of 5-hydroxytryptamine on tissue blood flow and microwave heating of tumors. Cancer Res. 45: 3203-3208, 1985.

37. Jirtle RL, Pierce, L.J., Crocker, I.R., and Strom, S.C. Radiation protection of rat parenchymal hepatocytes with S-2-(3-aminopropylamino)ethylphosphorothioic acid. Radiother. Oncol. 4: 231-237, 1985.

38. France, H.G., Mansbach, C.M., and Jirtle RL. Protection against colonic radiation injury in rats by intracolonic WR2721. Gastroenterology 91: 644-50, 1986.

39. Brooks, A.L., Guilmette, R.A., Hahn, R.R., and Jirtle RL. Uptake and clearance of 238Pu from liver cells transplanted into fat pads of Fisher 344 rats. Int. J. Radiat. Biol. 50:631-9, 1986.

40. Jirtle RL, and Michalopoulos, G. Enhancement of the clonability of adult parenchymal hepatocytes with the liver tumor promoter phenobarbital. Carcinogenesis 7: 1813-17, 1986.

41. Loury, D.J., Smith-Oliver, T., Strom, S., Jirtle RL, Michalopoulos, G., and Butterworth, B.E. Assessment of unscheduled and replicative DNA synthesis in hepatocytes treated in vivo and in vitro with unleaded gasoline of 2,2,4-trimethylpentane. Toxicol. Appl. Pharmacol. 85: 11-23, 1986.

42. Eckl, P.M., Whitcomb, W.W., Michalopoulos, G., and Jirtle RL. Effects of EGF and calcium on adult parenchymal hepatocyte proliferation. J. Cell Physiol. 132: 363-366, 1987.

43. Eckl, P.M., Strom, S.C., Michalopoulos, G., and Jirtle RL. Induction of sister chromatid exchanges in cultured adult rat hepatocytes by directly and indirectly acting mutagens/carcinogens. Carcinogenesis 8: 1077-1083, 1987.

44. Michalopoulos, G.K., Eckl, P.M., Cruise, J.L., Novicki, D.L., and Jirtle RL. Mechanisms of rodent liver carcinogenesis. Toxicol. Indust. Health 3: 119-128, 1987.

45. Jirtle RL. Chemical modification of tumor blood flow. Int. J. Hyperthermia 4: 355-371, 1988.

46. Alati, T., Van Cleeff, M., Strom, S.C., and Jirtle RL. Radiation sensitivity of adult human parenchymal hepatocytes. Radiat. Res. 115: 152-160, 1988.

47. Eckl, P.M., Meyer, S.A., Whitcomb, W.R., and Jirtle RL. Phenobarbital reduces EGF receptors and the ability of physiological concentrations of calcium to suppress hepatocyte proliferation. Carcinogenesis 9: 479-483, 1988.

48. Butterworth, B.E., Smith-Oliver, T., Earle, L., Loury, D.J., White, R.D., Doolittle, D.J., Working, P.K., Cattley, R.C., Jirtle RL, Michalopoulos, G., and Strom, S. Use of primary cultures of hepatocytes in toxicology studies. Cancer Res. 49: 1075-1084, 1989.

49. Meyer, S.A., and Jirtle,R.L. Phenobarbital decreases hepatocyte EGF receptor expression independent of protein kinase C activation. Biochem. Biophys. Res. Commun. 158: 652-659, 1989.

50. Alati, T., Van Cleeff, M., Strom, S.C., and Jirtle RL. Radiosensitivity of parenchymal hepatocytes as a function of oxygen concentration. Radiat. Res. 118: 488-501, 1989.

51. Alati, T., Eckl, P., and Jirtle RL. An in vitro micronucleus assay for determining the radiosensitivity of parenchymal hepatocytes. Radiat. Res. 119: 562-568, 1989.

52. Meyer, S.A., Gibbs, T.A., and Jirtle,R.L. Tumor promoters phenobarbital and 12-0-tetra-decanoyl-phorbol-13-acetate independently reduce EGF binding by rat hepatocytes. Cancer Res. 49: 5907-5912, 1989.

53. Gebhardt, R., Jirtle RL, Moorman, A.F.M., Lamers, W.H., and Michalopoulos, G. Induction of glutamine synthetase and transient co-expression with carbamoylphosphate synthetase in hepatocytes transplanted into fat pads of syngeneic hosts. Histochemistry 92: 337-342, 1989.

54. Joines, W.T., Shrivastav, S., and Jirtle RL. A comparison using tissue electrical properties and temperature rise to determine relative absorption of microwave power in malignant tissue. Med. Phys. 16: 840-844, 1989.

Articles from 1990-1994

55. Anscher, M.S., Crocker, I.R., and Jirtle RL. Transforming growth factor-b1 expression in irradiated liver. Radiat. Res. 122: 77-85, 1990.

56. Brockenbrough, J.S., Meyer, S.A., Li, C., and Jirtle RL. A reversible and phorbol ester-specific defect of protein kinase C translocation in hepatocytesd isolated from phenobarbital-treated rats. Cancer Res. 51: 130-136, 1991.

57. Jirtle RL, and Meyer, S.A. Liver tumor promotion: Effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-b1 expression. Digest. Dis. Sci. 36: 659-668, 1991.

58. Eckl, P.M., Alati, T., and Jirtle RL. The effects of a purified diet on sister chromatid exchange frequencies and mitotic activity in adult rat hepatocytes. Carcinogenesis 12: 643-646, 1991.

59. Jirtle RL, Carr, B.I., and Scott, C.D. Modulation of insulin-like growth factor-II/mannose 6-phosphate receptors and transforming growth factor-ß1 during liver regeneration. J. Biol. Chem. 266: 22444-22450, 1991.

60. Hwang, J.-J., Hsia, M.T.S., and Jirtle RL. Induction of sister chromatid exchanges and micronuclei in primary cultures of rat and human hepatocytes by the peroxisome proliferator, [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) Mutat. Res. 286: 123-133, 1993.

61. Anscher, M.S.,Peters, W.P., Reisenbichler, H., Petros, W.P., and Jirtle RL. Transforming growth factor b as a predictor for the development of liver and lung toxicity in advanced breast cancer patients treated with with dose chemotherapy and autologous bone marrow transplantation. N. Eng. J. Med. 328: 1592-1598, 1993.

62. Bursch, W., Oberhammer, F., Jirtle RL, Askari, M., Sedivy, R., Grasl-Kraupp, B., Purchio, A.F., and Schulte-Hermann, R. Transforming growth factor b1 as a signal for induction of cell death by apoptosis. Br. J. Cancer. 67: 531-536, 1993.

63. Eckl, P.M., Anderson-Carnahan, L., and Jirtle RL. Aquatic genotoxicity testing with rat hepatocytes in primary culture. I. SCE-induction. Sci. Total Environ. 136: 111-119, 1993.

64. Jirtle RL, Haag, J.D., Ariazi, E.A., and Gould, M.N. Increased Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor and TGF-b1 levels during monoterpene-induced regression of mammary tumors. Cancer Res. 53:3849-4127, 1993.

65. Zhang, Y., Joines, W.T., Jirtle RL, and Samulski, T.V. Theoretical and Measured Electric Field Distributions within an Annular Phased Array: Consideration of Source Antennas. IEEE Trans. Biomed. Eng. 40: 780-787, 1993.

66. Schulte-Hermann, R., Bursch, W., Kraupp-Grasl, B., Oberhammer, F., Wagner, A., and Jirtle RL. Cell proliferation and apoptosis in normal liver and preneoplastic foci. Environ. Health Perspect. 101: 87-90, 1993.

67. Takemoto-Hambleton, R., Joines, W.T., Jirtle RL, and Samulski, T.V. Modelling aperture antennas in the near- and far-field regions using subarrays of equivalent uniformly illuminated apertures. Int. J. Hyperthermia 9: 37-49, 1993.

68. Saperstein, L.A., Jirtle RL, Farouk, M., Thompson, H. J., Chung, K.S and Meyers, W.C. Transforming growth factor-b1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat. Hepatology 19: 412-417, 1994.

69. Joines, W.T., Zhang, Y., Li, C., and Jirtle RL. The measured electrical properties of normal and malignant human tissues from 50 to 900 MHz. Med. Phys. 21: 1-4, 1994.

70. Murase, T., Jirtle RL, and McDonald, G.B. TGF-b concentrations in the patients with lymphoma and leukemia receiving chemotherapy and marrow transplantation. Blood 83: 2383, 1994.

71. Anscher, M.S., and Jirtle RL. Role of transforming growth factor-b and hepatocyte growth factor in late normal tissue effects of radiation. Rad. Onc. Invest. 1: 305-313, 1994.

72. Jirtle RL, Hankins, G.R., Reisenbichler, H., and Boyer, I.J.. Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital. Carcinogenesis 15: 1473-1478, 1994.

73. Reisenbichler, H., and R.L. Jirtle. BSA treatment of plasticware reduces TGFß binding. Biotechniques 17: 675-676, 1994.

74. Anscher, M.S., Prescott, D.M., Marks, L.B., Reisenbichler, H., Murase, T., Bentel, Gunilla, C., Spencer, D., Sherouse, G., and Jirtle RL. Changes in plasma TGF-ß levels during pulmonary radiotherapy as predictor of the risk of developing radiation pneumonitis. Int. J. Radiat. Oncol. Biol. Phys. 30: 671-676, 1994.

75. Reisenbichler, H., Chari, R.S., Boyer, I.J., and Jirtle RL. Transforming growth factor-beta receptors type I, II and III in Phenobarbital-promoted rat liver tumors. Carcinogenesis 15: 2763-2767, 1994.

76. Murase, T., Anscher, M.S., Petros, W.P., Peters, W.P., and Jirtle RL. Changes in plasma TGF-ß in response to high-dose chemotherapy for stage II breast cancer: Implications for the prevention of hepatic venoocclusive disease and idiopathic interstitial pneumonitis. Bone Marrow Transplant. 30: 671-676, 1994.

Articles from 1995-1999

77. Andersen, M.E., Mills J.J., Jirtle RL, and Greenlee, W.F. Negative selection in hepatic tumor promotion in relation to cancer risk assessment. Toxicology 102: 223-237, 1995.

78. Chari, R.S, Price, D.T., Sue, S.R., Meyers, W.C., and Jirtle RL. Down-regulation of transforming growth factor beta receptors type I, II and III during liver regeneration. Am. J. Surg. 169: 126-132, 1995.

79. Mills, J.J., Chari, R.S., Boyer, I.J., Gould, M.N., and Jirtle RL. Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Res. 55: 979-983, 1995.

80. Anscher, M.S., Kong, F.-M., Murase, T., and Jirtle RL. Normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGFß. Br. J. Radiol. 68: 331-333, 1995.

81. De Souza, A.T., Hankins, G.R., Washington, M.K., Fine, R.L., Orton, T.C., and Jirtle RL. Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors. Oncogene 10: 17251729, 1995.

82. Sue, S.R., Chari, R.S., Kong, F.-M., Mills, J.J. Fine, R.L., and Jirtle RL, Meyers, W.C. Transforming growth factor beta receptors and mannose 6-phosphate/Insulin-like growth factor II receptor expression in human hepatocellular carcinomas. Ann. Surg. 222: 171-178, 1995.

83. Kong, F.-M.., Anscher, M.S., Murase, T., Abbott, B.D., Iglehart, J.D., and Jirtle RL. Elevated plasma transforming growth factor ß1 levels in breast cancer patients decrease following surgical removal of the tumor. Ann. Surg. 222: 155-162, 1995.

84. Lawrence, T.S., Robertson, J.M., Anscher, M.S., Jirtle RL, Ensminger, W.D., and Fajardo, L.F. Hepatic toxicity resulting from cancer treatment. Int. J. Radiat. Oncol. Biol. Phys. 31: 1237-1248, 1995.

85. Song, J. J., Celeste, A. J., Kong, F. M., Jirtle RL, Rosen, V. and Thies, S. Bone morphorgenetic protein-9 binds to liver cells and stimulates proliferation. Endocrinology 136(10): 4293-4297, 1995.

86. Barcellos-Hoff, M.H., Ehrhart, E.J., Kahlia, M., K., Jirtle RL, Flanders, K., and Tsang, M.L.-S. Immunohistochemical identification of active TGF-ß in situ using engineered tissue. Am. J. Pathol. 147(5): 1228-1237, 1995.

87. De Souza A.T., Hankins, G.R., Washington, M.K., Orton, T.C., and Jirtle RL. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat. Genet. 11: 447-449, 1995. [PDF]

88. Mansbach, J.M., Mills, J.J., Boyer, I. J., De Souza, A.T., Hankins, G.R., and Jirtle RL, Phenobarbital selectively promotes initiated cells with reduced TGFß receptor levels. Carcinogenesis 17: 171-174, 1996. [PDF]

89. Hankins, G.R., De Souza, A.T., Bentley, R.C., Patel, M.R., Marks, J.R., Iglehart, J.D., and Jirtle RL, M6P/IGF2 receptor: a candidate breast tumor suppressor gene. Oncogene 12: 2003-2009, 1996.

90. Kong, F.-M., Washington, M.K. Jirtle RL. and Anscher, M.S. Plasma transforming Growth Factor ß1 reflects disease status in patients with lung cancer after radiotherapy: a possible tumor marker. Lung Cancer 16: 47-59, 1996.

91. De Souza, A.T., Mills, J.J., Yamada, T., and Jirtle RL. Imprinted genes in liver carcinogenesis. FASEB J. 11: 60-67, 1997. [PDF]

92. Anscher, M.S., Kong, F.M., Marks, L.B., Bentel, G.C., and Jirtle RL, Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis. Int. J. Radiat. Oncol. Biol. Phys. 37: 253-258, 1997.

93. Yamada,T., De Souza, A.T., Finkelstein,S., and Jirtle RL. Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis. Proc. Natl. Acad. Sci. USA 94: 10351-10355, 1997. [PDF]

94. DiPaola, R.S., Weiss, R.E., Cummings, K.B., Kong, F.-M., Jirtle RL, Anscher, M., Gallo, J., Goodin, S., Thompson, S., Rasheed, Z., Aisner, J., Todd, M., Effect of 13 cis-retinoic acid and alpha interferon on transforming growth factor-ß1 in patients with rising prostate specific antigen. Clin. Cancer Res. 11: 1999-2004, 1997.

95. Isfort, R.J., Cody, D.B., Doersen, C.J., Richards, W.G., Yoder, B.K., Wilkinson, J.E., Kier, L.D., Jirtle RL, Isenberg, J.S., Klounig, J.E. and Woychik, R.P. The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene. Oncogene 15: 1797-1803, 1997.

96. Mills, J.J., Falls, J.G., De Souza, A.T., and Jirtle RL. Imprinted M6p/Igf2 receptor is mutated in rat liver tumors. Oncogene 16: 2797-2802, 1998. [PDF]

97. Anscher, M.S., Kong, F.-M., Andrews, K., Clough, R., Marks, L.B., Bentel, G., and Jirtle RL. Plasma transforming growth factor ß1 as a predictor of radiation pneumonitis. Int. J. Radiat. Oncol. Biol. Phys. 41: 1029-1035, 1998.

98. Anscher, M.S., Kong, F.-M., and Jirtle RL. The relevance of transforming growth factor ß1 in pulmonary injury after radiation therapy. Lung Cancer 19: 109-120, 1998.

99. Pulford, D.P., Falls, J.G., Killian, J.K., and Jirtle RL. Polymorphisms, genomic imprinting and cancer susceptibility. Mutat. Res. 436: 59-67, 1999. [PDF]

100. Killian, J.K., and Jirtle RL. Genomic Structure of the Human M6P/IGF2 Receptor. Mamm. Genome 10: 74-77, 1999. [PDF]

101. Falls, J.G., Pulford, D.J., Wylie, A.A., and Jirtle RL. Genomic imprinting: implications in human disease. Am. J. Pathol. 154: 635-647, 1999. [PDF]

102. Jirtle RL. Genomic imprinting and cancer. Exp. Cell Res. 248: 18-24, 1999. [PDF]

103. Yan, Y., Todaka, N., Yamamura, K., Hirano, H., Gotoh, S., Katoh, T., Higashi, K., Arai, S., Murata, Y., Higashi, T., and Jirtle RL. The occurrence of polymorphism of mannose 6-phosphate/insulin-like growth factor 2 receptor gene in laboratory and wild rats. Sangyo Ika Daigaku Zasshi 21: 199-208, 1999.

104. Kong, F., Jirtle RL, Huang, D.H., Clough, R.W., and Anscher, M.S. Plasma transforming growth factor-beta1 level before radiotherapy correlates with long term outcome of patients with lung carcinoma. Cancer 86: 1712-1719, 1999.

105. Devi, G.R., De Souza, A.T., Byrd, J.C., Jirtle RL, and MacDonald, R.G. Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers. Cancer Res. 59: 4314-4319, 1999.

106. Byrd, J.C., Devi, G.R., De Souza, A.T., Jirtle RL, and MacDonald, R.G. Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations. J. Biol. Chem. 274: 24408-24416, 1999.

Articles from 2000-2005

107. Kong F.M., Anscher, M.S., Washington, M.K., Killian, J.K., and Jirtle RL. M6P/IGF2R is mutated in squamous cell carcinoma of the lung. Oncogene 19:1572-1578, 2000.

108. Dalton, S.R., Jirtle RL, and Meyer S.A. EGF receptors of hepatocytes from rats treated with phenobarbital are sensitized to down-regulation by phenobarbital in culture. Toxicol. Appl. Pharmacol. 165:115-126, 2000.

109. Jirtle RL, Sander, M., and Barrett, J.C. Genomic imprinting and environmental disease susceptibility. Environ. Health Perspect. 108: 271-278, 2000.

110. Murphy, S.K., and Jirtle RL. Imprinted genes as potential genetic and epigenetic toxicologic targets. Environ. Health Perspect. 108 (Suppl 1): 5-11, 2000. [PDF]

111. Killian, J.K., Byrd, J.C, Jirtle, J.V., Munday, B.L., Stoskopf, M.K., and Jirtle RL. M6P/IGF2R imprinting evolution in mammals. Mol. Cell 5: 707-716, 2000. [Press Release] [PDF]

112. Wylie, A.A., Murphy, S.K., Orton, T.C., and Jirtle RL. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. Genome Res. 10: 1711Ð1718, 2000. [PDF]

113. Murphy, S.K, Wylie, A.A., and Jirtle RL. Imprinting of PEG3,the human homolog of a mouse gene involved in nurturing behavior. Genomics 71: 110-117, 2001. [Press Release] [Journal Cover] [PDF]

114. Kong, F.M., Anscher, M.S., Sporn, T.A., Washington, M.K., Clough, R., Barcellos-Hoff, M.H., and Jirtle RL. Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury. Int. J. Radiat. Oncol. Biol. Phys. 49:35-41, 2001.

115. Killian, J.K., Buckley, T.R., Stewart, N., Barry L. Munday, B.L., and Jirtle RL. Marsupials and eutherians reunited: genetic evidence for the theria hypothesis of mammalian evolution. Mamm. Genome 12: 513-517,2001. [Press Release] [Journal Cover] [PDF]

116. Nolan, C.M., Killian, J.K., Petitte, J.N., and Jirtle RL. Imprint status of M6P/IGF2R and IGF2 in chickens. Dev. Genes Evol. 211: 179-183, 2001. [PDF]

117. Killian, J.K., Oka, Y., Jang H.-S., Fu, X., Waterland, R.A., Sohda, T., Sakaguchi, S., and Jirtle RL. Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations. Hum. Mutat. 18: 25-31, 2001. [PDF]

118. Killian,J.K., Nolan, C.M., Stewart, N., Munday, B.L. Andersen, N.A., Stewart Nicol, S., and Jirtle RL. Monotreme IGF2 expression and ancestral origin of genomic imprinting. J. Exp. Zoology 291:205-212, 2001. [Journal Cover] [PDF]

119. Fu, X.L., Huang, H., Bentel, G., Clough, R., Jirtle RL, Kong, F.M., Marks, L.B., and Anscher, M.S. Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta. Int. J. Radiat. Oncol. Biol. Phys. 50: 899-908, 2001.

120. Killian, J.K., Nolan C.M., Wylie A.A., Li T., Vu T.H., Hoffman A.R., and Jirtle RL. Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary. Hum. Mol. Genet. 10: 1721-1728, 2001. [Press Release] [Journal Cover] [PDF]

121. Anscher, M.S., Marks, L.B., Shafman, T.D., Clough, R., Huang, H., Tisch, A., Munley, M., Herndon, J.E., 2nd, Garst, J., Crawford, J., and Jirtle RL. Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalation. J. Clin. Oncol. 19: 3758-3765, 2001.

122. Evans, H.K., Wylie, A.A., Murphy, S.K., and Jirtle RL. The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2. Genomics 77: 99-104, 2001. [PDF]

123. Killian, J.K., Nolan, C.M., and Jirtle RL. The evolution of genomic imprinting in Jurassic mammals. In Genetic Resources for the Next Century. O. Ryder, ed. University of California Press, San Diego., 2001.

124. Oka, Y., Waterland, R.A., Killian, J.K., Nolan, C.M., Jang, H.S., Tohara, K., Sakaguchi, S., Yao, T., Iwashita, A., Yata, Y., Takahara, T., Sato, S.I., Suzuki, K., Masuda, T., and Jirtle RL. M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan. Hepatology 35: 1153-1163, 2002. [PDF]

125. Li, T., Vu, T.H., Lee, K.O., Yang Y., Nguyen, C.V., Bui, H.Q., Zeng, Z.L., Nguyen, B.T., Hu, J.F., Murphy, S.K., Jirtle RL, and Hoffman, A.R. An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. J. Biol. Chem. 277: 13518-27, 2002. [PDF]

126. Freking, B.A., Murphy, S.K., Wylie, A.A., Rhodes, S.J., Keele, J.W., Leymaster, K.A., Jirtle RL, and Smith, T.P. Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals. Genome Res. 12: 1496-1506, 2002. [Press Release] [Journal Cover] [PDF]

127. Wylie, A.A., Pulford, D.J., McVie-Wylie, A.J., Waterland, R.A., Evans, H.K., Chen, Y.T., Nolan, C.M., Orton, T.C., and Jirtle RL. Tissue-specific inactivation of murine M6P/IGF2R. Am. J. Pathol. 162: 321-328, 2003. [PDF]

128. Jamieson, T.A., Brizel, D.M., Killian, J.K., Oka, Y., Jang, H.-S., Fu, X., Clough, R.W., Vollmer, R.T., Anscher, M.S., and Jirtle RL. M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis. BMC Cancer 3: 4, 2003. [PDF]

129. Prosnitz, R.G., Anscher, M.S., Huang, H., Clough, R., Jirtle RL, and Marks, L.B. Does pre-treatment plasma transforming growth factor beta (TGF-beta1) level predict outcome in breast cancer patients following radiotherapy? Int. J. Radiat. Oncol. Biol. Phys. 57(2 Suppl): S202-S203, 2003.

130. Dietz, L.G., Wylie, A.A., Rauen, K.A., Murphy, S.K., Jirtle RL, and Cotter, P.D. Exclusion of maternal uniparental disomy of chromosome 14 in patients referred for Prader-Willi syndrome using a multiplex methylation polymerase chain reaction assay. J. Med. Genet. 40: e46, 2003. [PDF]

131. Anscher, M.S., Marks, L.B., Shafman, T.D., Clough, R., Huang, H., Tisch, A., Munley, M., Herndon, J.E., Garst, J., Crawford, J., Jirtle RL. Risk of long-term complications after TFG-beta1-guided very-high-dose thoracic radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 56: 988-995, 2003.

132. Murphy, S.K., and Jirtle RL. Imprinting Evolution and the Price of Silence. BioEssays: 25: 577-588, 2003. [Journal Cover] [PDF]

133. Waterland, R.A. and Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol. Cell Biol. 23: 5293-5300, 2003. [Press Release] [Journal Cover] [PDF]

134. Murphy SK, Wylie, A.A., Coveler, K.J., Cotter, P.D., Papenhausen, P.R., Sutton, V.R., Shaffer, L.G., and Jirtle RL. Epigenetic detection of human chromosome 14 uniparental disomy Hum. Mutat. 22: 92-97, 2003. [PDF]

135. Waterland, R.A, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20: 63-68, 2004. [PDF]

136. Jirtle RL. IGF2 loss of imprinting: a potential heritable risk factor for colorectal cancer. Gastroenterology 126: 1190-1193, 2004. [Journal Cover] [PDF]

137. Weidman, J.R., Murphy, S.K., Nolan, C.M., Dietrich, F.S., and Jirtle RL. Phylogenetic footprint analysis of IGF2 in extant mammals. Genome Res. 14: 1726-1732, 2004. [Journal Cover] [PDF]

Articles from 2005-present

138. Murphy, S.K., Freking, B.A., Smith, T.P.L., Leymaster, K., Nolan, C.M., Wylie, A.A., Evans, H.K., and Jirtle RL. Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep. Mamm. Genome 16: 171-183, 2005. [PDF]

139. Evans, H.K., Weidman, J.R, Cowley, D.O., and Jirtle RL. Comparative phylogenetic analysis of Blcap/Nnat reveals eutherian-specific imprinted gene. Mol. Biol. Evol. 22: 1740-1748, 2005. [PDF]

140. Luedi, P.P., Hartemink, A.J., and Jirtle RL. Genome-wide prediction of imprinted murine genes. Genome Res. 15: 875-884, 2005. [PDF]

141. Weidman, J.R., Maloney, K.A., and Jirtle RL. Comparative phylogenetic analysis reveals multiple non-imprinted isoforms of opossum Dlk1. Mamm. Genome 17: 157-167, 2006. [PDF]

142. Nolan, C.M., McCarthy, K., Eivers, E., Jirtle RL, and Byrnes, L. Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish. Dev. Genes Evol. 216: 144-151, 2006. [PDF]

143. Hu, C.K., McCall, S., Madden, J., Huang, H., Clough, R., Jirtle RL, and Anscher, M.S. Loss of heterozygosity of M6P/IGF2R gene is an early event in the development of prostate cancer. Prostate Cancer Prostatic Dis. 9: 62-67, 2006.

144. Murphy, S.K., Nolan, C.M., Huang, Z., Kucera, K.S., Freking, B.A., Smith, T.P.L., Leymaster, K.A., Weidman, J.R., and Jirtle RL The Callipyge mutation affects gene expression in cis: a role for chromatin structure? Genome Res. 16: 340-346, 2006. [PDF]

145. Dolinoy, D.C., Weidman, J.R., Waterland, R.A., and Jirtle RL Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ. Health Perspect. 14: 567-572, 2006. [PDF]

146. Waterland, R.A., Lin, J.-R., Smith, C.A., and Jirtle RL Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum. Mol. Genet. 15: 705-716, 2006. [PDF]

147. Weidman, J.R., Dolinoy, D.C., Maloney, K.A., Cheng, J.-F., and Jirtle RL Imprinting of opossum Igf2r in the absence of differential methylation and Air. Epigenetics 1: 49-54, 2006. [PDF]

148. Vu, T.H., Jirtle RL, and Hoffman, A.R. Cross-species clues of an epigenetic imprinting regulatory code for the IGF2R gene. Cytogenet. Genome Res. 113: 202-208, 2006. [PDF]

149. Abel, K.M., Allin, M.P., and Jirtle RL Schizophrenia, cancer and imprinting: early nutritional influences. Br. J. Psychiatry 188: 394, 2006. [PDF]

150. Liddle, R.A., and Jirtle RL. Epigenetic silencing of genes in human colon cancer. Gastroenterology 131: 960-962, 2006. [PDF]

151. Bobetsis, Y.A., Barros, S.P., Lin, D.M., Weidman, J.R., Dolinoy, D.C., Jirtle RL, Boggess, K.A., Beck, J.D., and Offenbacher, S. Bacterial Infection Promotes DNA Hypermethylation. J. Dental Res. 86: 169-174, 2007. [PDF]

152. Shevchenko, A.I., Zakharova, I.S., Elisaphenko, E.A., Kolesnikov, N.N., Whitehead, S., Bird, C., Ross, M., Weidman, J.R,. Jirtle RL, Karamysheva, T.V., Rubtsov, N.B., VandeBerg, J.L., Mazurok, N.A., Nesterova, T.B., Brockdorff, N., and Zakian, S.M. Genes flanking Xist in mouse and human are separated on the X chromosome in American marsupials. Chromosome Res. 15: 127-136, 2007. [PDF]

153. Dolinoy, D.C., Weidman, J.R., and Jirtle RL. Epigenetic gene regulation: Linking early developmental environment to adult disease. Reprod. Toxicol. 23: 297-307, 2007. [PDF]

154. Dolinoy, D.C., Das, R., Weidman, J.R., and Jirtle RL. Metastable epialleles, imprinting, and the fetal origins of adult diseases. Pediatric Res. 61: 30R-37R, 2007. [PDF]

155. Weidman, J.R., Dolinoy, D.C., Murphy, S.K., and Jirtle RL. Cancer susceptibility: epigenetic manifestation of environmental exposures. Cancer J. 13: 9-16, 2007.

156. Jirtle RL, and Weidman, J.R. Imprinted and more equal. Am. Sci. 95: 143-149, 2007. [PDF]

157. Jirtle RL, and Skinner, M.K. Environmental epigenomics and disease susceptibility. Nat. Rev. Genet. 8: 253-562, 2007. [PDF]

158. Mikkelsen, T.S., Wakefield, M.J., Aken, B., Amemiya, C.T., Chang, J.L., Duke, S., Garber, M., Gentles, A.J., Goodstadt, L., Heger, A., Jurka, J., Kamal, M., Mauceli, E., Searle, S.M., Sharpe, T., Baker, M.L., Batzer, M.A., Benos, P.V., Belov, K., Clamp, M., Cook, A., Cuff, J., Das, R., Davidow, L., Deakin, J.E., Fazzari, M.J., Glass, J.L., Grabherr, M., Greally, J.M., Gu, W., Hore, T.A., Huttley, G.A., Kleber, M., Jirtle RL, Koina, E., Lee, J.T., Mahony, S., Marra, M.A., Miller, R.D., Nicholls, R.D., Oda, M., Papenfuss, A.T., Parra, Z.E., Pollock, D.D., Ray, D.A., Schein, J.E., Speed, T.P., Thompson, K., VandeBerg, J.L., Wade, C.M., Walker, J.A., Waters, P.D., Webber, C., Weidman, J.R., Xie, X., Zody, M.C.; Broad Institute Genome Sequencing Platform; Broad Institute Whole Genome Assembly Team, Graves, J.A., Ponting, C.P., Breen, M., Samollow, P.B., Lander, E.S., and Lindblad-Toh, K. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature 447: 167-177, 2007. [PDF]

159. Dolinoy DC, Huang, D., and Jirtle RL. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc. Natl. Acad. Sci. USA 104: 13056-13061, 2007. [Press Release] [PDF]

160. Luedi, P.P., Dietrich, F.S., Weidman, J.R., Bosko, J.M., Jirtle RL, and Hartemink, A.J. Computational and experimental identification of novel human imprinted genes. Genome Res. 17: 1723-1730, 2007. [Press Release] [Journal Cover] [PDF]

161. Dolinoy, D.C., and Jirtle RL. Environmental epigenomics in human health and disease. Environ. Mol. Mutagen 9: 4-8. 2008. [PDF]

162. Jirtle RL. Randy L. Jirtle, PhD: epigenetics a window on gene dysregulation, disease. Interview by Bridget M. Kuehn. JAMA, 299: 1249-1250, 2008. [PDF]

163. Jang, H.S., Kang, K.M., Choi, B.O., Chai, G.Y., Hong, S.C., Ha, W.S., and Jirtle RL. Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma. World J. Gastroenterol., 14: 1394-1398, 2008. [PDF]

164. American Association for Cancer Research Human Epigenome Task Force; European Union, Network of Excellence, Scientific Advisory Board. Moving AHEAD with an international human epigenome project. Nature, 454: 711-715, 2008. [PDF]